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KMID : 0385020040200020165
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Korean Journal of Laboratory Animal Science
2004 Volume.20 No. 2 p.165 ~ p.170
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Study on c-fos Expression in the Lumbar Spinal Cord of Sciatic Nerve Injured Rats by Ultrasound Application
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Kim Young-Chul
Kim Dong-Dae
Kim Jin-Sang
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Abstract
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To evaluate the effects of low-intensity ultrasound application to sciatic nerve injured rats on c-fos expression in the lumbar spinal cord, various continuous-wave ultrasound treatments with intensities of 0.2W/cm2, 0.5W/cm2 and 1.0W/cm2 operated at 1MHz or sham treatment were applied to the opposite inside of the nerve injury site for 1 minute every other day with a transducer moving speed of 2 cm/sec. c-Fos expression was markedly increased at 1hour after sciatic nerve injury, then gradually decreased thereafter. c-Fos expressions were significantly decreased (p < 0.05) in all the experimental groups in comparison with the control group until 3days post-injury, and the degrees of decrease were higher in 0.5W/cm2 and 1W/cm2 intensity ultrasound application groups. However, no significant difference in c-fos expressions was observed between the experimental groups and the control group after 7 days post-injury. Therefore, it is suggested that low-intensity ultrasound application after peripheral nerve injury suppresses a pain transmission.
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KEYWORD
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Ultrasound, Sciatic nerve injury, c-fos expression, Lumbar spinal cord
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